Prevention of Cardiovascular Complications from Drug Overdose Emergencies
Project Grant ID: 1R01DA037317 NIH/NIDA
Chief Investigators: Manini, Wax, Brent
Administering Institutions: Mount Sinai School of Medicine
Funding period: 2014-2019
Synopsis: A prospective cohort study of ED overdose patients to 1) evaluate high risk genetic polymorphisms that are predictive of drug overdose fatality; (2) Evaluate serum biomarkers that predict tissue/organ injury from drug toxicity; and (3) prospectively validate a previously derived clinical risk tool in the Toxicology Investigators’ Consortium (TOXIC), a robust registry of over 70 hospital centers with bedside medical toxicology evaluation of ED overdose patients.
NIDA National Early Warning System Network (iN3): An Innovative Approach
Project Grant ID: R56 1 R56DA038366 NIH/NIDA
Chief Investigators: Carlson, Sheth, Boyer, Wax, Brent
Administering Institutions: Wright State University
Funding period: 2014-2016
Synopsis: The goal of this study is to establish an advanced surveillance system for emerging drug use in the U.S. by harmonizing data from web-based sources associated with emerging drug use and a network of sentinel sites for emerging drug use staffed by medical toxicologists.
Supplemental Translational Proposal for the Utilization of the ToxIC Network to Study High Dose Chemical Threat Agent Exposures in Humans
Project Grant ID: WA00190374/RFS2014140 NIH/NINDS
Chief Investigators: Bird, Wax, Brent, Hatten
Administering Institutions: University of Massachusetts
Funding period: 2013-2014
Synopsis: The purpose of this supplemental award is to investigate the use of the Toxicology Investigators Consortium (ToxIC) Registry for clinical information on actual cases of chemical threat agent poisoning.
NDEWS - Development of ToxIC Briefs
Project Grant ID: Subcontract to the NIDA funded National Drug Early Warning System (NDEWS)
Chief Investigators: Wax, Brent
Administering Institutions: American College of Medical Toxicology
Funding period: 2018-2019
Synopsis: The purpose of this agreement is to provide pilot funding to develop ToxIC Briefs - short form reports from the ToxIC Registry - that would serve as a means to disseminate observations from the ToxIC Registry to the NDEWS program who then disseminate these reports to their vast array of partners with an interest in novel drugs of abuse.