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Selected Projects

Alcohol Intoxication, Co-ingestion and Withdrawal in Medical Toxicology Consultations

Description: The Toxic Investigators Consortium (ToxIC) was developed by the American College of Medical Toxicology in January, 2010 to track patients seen by MTCS and to provide an infrastructure for research. In order to obtain information for further study, and for use in QA/QI projects involving ToxIC data entry, we reviewed and analyzed registry data regarding alcohol intoxication, co-ingestion and alcohol-withdrawal syndrome (AWS).

Principal Investigator:  Tim Wiegand (Project ID#2011_03)

Deliverables:  Abstract 2011 NACCT6

Bupropion: An Atypical Cause of Serotonin Syndrome Report from the ToxIC Registry

Description:  Describe the patients with serotonin syndrome in association with bupropion as reported to the Toxicology Investigators Consortium (ToxIC).

Principal Investigator:  Diane Calello (Project ID#2014_08)

Deliverables:  Abstract 2015 ACMT ASM1

Cases of QT Interval Prolongation in the ToxIC Database

Description:  Our objective is to describe the cohort of cases of QT interval prolongation reported to the ToxIC (Toxicology Investigators Consortium) Registry in order to better characterize the clinical effects in these patients.

Principal Investigator:  Chris Hoyte (Project ID#2013_07)

Deliverables:  Abstract 2013 NACCT6 

Characterizing Herbals and Dietary Supplements Toxicities using the ToxIC Registry

Description:  To characterize herbals and dietary supplements toxicities using preliminary data from the ToxIC registry.

Principal Investigator:  Amy Zosel (Project ID#2012_08)

Deliverables:  Abstract 2012 NACCT6  

Characteristics of Salicylate Ingestions Reported to the ToxIC Registry

Description:  Characterize all salicylate cases within the ToxIC registry through 4-2014

Principal Investigator:  Rita McKeever (Project ID#2014_11)

Deliverables:  Abstract 2014 NACCT6 

Chelation Therapy by Medical Toxicologists in the U.S.

Description:  We investigated the Toxicologic investigators Consortium (ToxIC) Registry data of the American College of Medical Toxicologist (ACMT) to see the frequency and pattern of chelation therapy among medical toxicologists in the US.

Principal Investigator:  A. Obefami (Project ID#2012_06)

Deliverables:  Abstract 2012 NACCT6

Comparison of ToxIC and NPDS Data

Description:  Data from the ToxIC Registry (Jan 1, 2010 – Apr 1, 2011) was compared with the most recently published NPDS data from the 2009 AAPCC NPDS report.

Principal Investigator:  Kurt Kleinschmidt (Project ID#2011_01) 

Deliverables:  Abstract 2011 NACCT6

Drug-Induced Hallucinations in Children and Teenagers Presenting to Emergency Departments

Description:  To identify the medications and substances that were most commonly used by children and teenagers who presented to the ED with/or developed hallucinations, and whose evaluation involved a medical toxicology consultation Jan 2010 – June 2014.

Principal Investigator:  Yaron Finkelstein (Project ID#2013_01)

Deliverables:  Pediatr Emerg Care7 2015 Oct 13

Features of Synthetic Cannabinoid Exposures: Report from the ToxIC Registry

Description:  Synthetic cannabinoid (SC) exposures often prompt ED visits and toxicology consultation. All cases entered into ToxIC from 2011 to October 2014 selected as “Bath Salt, Synthetic Cannabinoid, other Drug, or Agent referred to by a Street Name” were then  sorted to identify SC cases.

Principal Investigator:  Diane Calello (Project ID#2011_03)

Deliverables:  Abstract 2015 ACMT ASM1

Gender Differences in Prescription Medication Abuse

Description:  The current study aims to examine gender differences encountered in healthcare facilities with regard to the most commonly abused prescription drugs as reported in the ToxIC database 2010-2013.

Principal Investigator:  Jennifer Carey (Project ID#2014_01)

Deliverables:  Abstract 2014 Acad Emerg Med2

Hyperkalemia Does Not Predict Outcome From Digoxin Excess in Patients With Renal Dysfunction

Description:  Single center IRB-approved retrospective chart review of all hospitalized patients with an elevated digoxin serum concentration (>1.2 ng/mL) and evaluated the correlation between plasma potassium, digoxin concentration and mortality.

Principal Investigator:  Chuck McKay (Project ID# 2011_02)

Deliverables:  Abstract 2011 NACCT6

Intentional Pharmaceutical Overdoses Related to Therapeutic Misadventures: A Description of ToxIC Entries

Description:  Retrospective review of the ACMT ToxIC Case Registry analyzing data from the intentional pharmaceutical overdoses.

Principal Investigator:  B. Abar (Project ID#2015_02)

Deliverables:  Abstract 2015 ACMT ASM1

Intentional Pharmaceutical Overdoses: Comparison of Self-harm, Misuse/abuse and Therapeutic Misadventure ToxIC Case Registry Entries

Description:  Retrospective review of the ACMT ToxIC Case Registry analyzing data from the intentional pharmaceutical overdoses.

Principal Investigator:  Tim Wiegand (Project ID#2015_07)

Deliverables:  Abstract 2015 ACMT ASM1

Medical Toxicology Referrals in the Acute Care Setting

Description:  Medical Toxicologists (MT) evaluate patients in several different acute care settings. The types of providers whom request such services have not been defined. We queried the ToxIC Registry database to better understand the source of toxicology referrals.

Principal Investigator:  Evan Schwarz (Project ID#2012_07)

Deliverables:  Abstract 2012 NACCT6

Naloxone Administration in the Pediatric Population in ToxIC

Description:  To characterize patients age 

Principal Investigator:  Laura Fil (Project ID#2015_04)

Deliverables:  Abstract 2014 ACMT ASM1

Non-APAP Hepatotoxicity

Description:  What is the prevalence of non-acetaminophen (APAP) containing xenobiotics associated with AST > 1,000 as seen by medical toxicologists reporting to the ToxIC Registry (May 1, 2012 - October 30, 2013)?

Principal Investigator:  Nancy Onisko (Project ID#2013_15)

Deliverables:  Abstract 2014 ACMT ASM1 

Non-Ethanol Hyperlipasemia

Description:  Review case in the Toxicology Investigators Consortium (ToxIC) database of the American College of Medical Toxicology to investigate which xenobiotics other than ethanol were associated with hyperlipasemia.

Principal Investigator:  Jhonny Ordonez (Project ID#2013_08)

Deliverables:  Abstract 2013 NACCT6

Pediatric Laundry Detergent Pod Exposures: The ToxIC Experience

Description:  To describe the cases in ToxIC (through April 2014) involving laundry detergent pods.

Principal Investigator:  Diane Calello (Project ID#2014_12)

Deliverables:  Abstract 2014 NACCT6

Poisoning during Pregnancy: Observations from ToxIC

Description:  This study reviewed data on chemical substances that are associated toxicologic disease in pregnant women as reported to ToxIC.

Principal Investigator:  Yaron Finkelstein (Project ID#2012_1)

Deliverables:  J Med Toxicol5 2015 Sep;11(3):301-8.  

Street Drug Exposures in Hospitalized Patients as Reported in the ToxIC Registry - 2010 to 2014

Description:  The purpose of this study is to evaluate the frequency of street drug exposures in hospitalized patients seen by members of the Toxicology Investigators Consortium 2010-2014.

Principal Investigator:  Anna Arroyo-Plasencia (Project ID#2014_27)

Deliverables:  Abstract 2015 ACMT ASM1

The Differential Use of Physostigmine by Toxicologists in Anticholinergic Toxicity based on Offending Agent

Description:  To determine the rate of physostigmine use in those who exhibited an anticholinergic toxidrome.

Principal Investigator:  Joseph Watkins (Project ID#2014_10)

Deliverables:  Abstract 2014 ACMT ASM1 

Use of Insulin-Euglycemia in ToxIC

Description:  In cases of presumed single drug poisoning, what are the most common indications for medical toxicologists to use insulin euglycemia therapy?

Principal Investigator:  Paul Wax (Project ID#2015_06)

Deliverables:  Abstract 2015 ACMT ASM1

Use of Hemodialysis

Description:  The aim of this study to describe the use of hemodialysis in medical toxicology practice through review of the ToxIC Registry and to compare it to the AAPCC experience.

Principal Investigator:  T. Schwartz (Project ID#2013_09)

Deliverables:  Abstract 2013 NACCT6

Use of Multidose AC in the ToxIC Registry

Description:  Do current MDAC treatment practices by toxicologists involved in the Toxicologic Investigators Consortium align with published guidelines? We reviewed the ToxIC Case Registry in its entirety (2010–present) for cases involving MDAC treatment. Descriptive statistics were used for analysis.

Principal Investigator:  S. Ahari (Project ID#2014_04)

Deliverables:  Abstract 2014 ACMT ASM1 


1 ACMT ASM: American College of Medical Toxicology Annual Scientific Meeting

2 Acad Emerg Med: Academy of Emergency Medicine Annual Meeting

3 Clin Toxicol: Clinical Toxicology [Journal, Taylor Francis]

4 EAPCCT: European Association of Poisons Centres and Clinical Toxicologists Annual Meeting

5 J Med Toxicol: Journal of Medical Toxicology [Springer]

6 NACCT: North American Congress of Clinical Toxicology Annual Meeting

7 Pediatr Emerg Care: Pediatric Emergency Care [Journal, Wolters Kluwer]

Other Completed Projects

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z


A Characterization of Cases of Severe Hyperthermia

A Comparative Study of Acetaminophen Exposures (P.I. Ordonez, Project #2013_18) 

A Descriptive Study of Prescription Opioid Misusers

A Prospective Comparison of the Results of Endoscopy and Computerized Tomography in Cases of Acute Ingestions of Corrosive Agents (P.I. Livshitz, Project #2012_02_S)

Antibiotic Use in the Management of Snake Envenomation. (see Sub Registry Projects: NASBR)

Assessment of Patterns of Substance Abuse among Adolescents and the Associated Severity of Outcome: a 5-Year Retrospective Cohort Study. (P.I. Rickner, Project #2015_15)


Bedside Evaluation of Adverse Drug Events (P.I. Farmer, Project #2011_03) 


Characterizing Flumazenil Use (P.I. Laes, Project #2013_14)

Characteristics of Intentional Self-Poisonings in Adolescents versus Adults in ToxIC Case Registry Entries. 

Characteristics of Patients Presenting for Exposure to Heavy Metals (P.I. Farrugia, Project #2013_11)

Chemical Threat Agent Exposures Reported in the ToxIC Registry (P.I. Hatten, Project #2014_06_C)

Clinical Presentation and Complications of Patients after Exposure to Substances Labeled “Bath Salts” (P.I. Froberg, Project #2011_04)

Current and Emerging Trends of the use of Observation Units by Medical Toxicologists for Poisoned Patients (P.I. Judge, Project #2014_02)

Cutting to the Chase: Observations on Debridement in Crotalid Envenomation reflected in the ToxIC North American Snakebite Registry (see Sub Registry Projects: NASBR: Sub Project P.I. Ruha)


Descriptive Study of Medical Toxicology Consultations at a Teaching University Hospital in Bangkok. (International Sub Registry - Suspended) 

Development of an International Registry of Poisoned Patients. (International Sub Registry - Suspended) 


Elder Toxicology: Characterizing Intentional Pharmaceutical Exposures in the Aged Population Using the ToxIC Registry. (P.I. Boroughf, Project #2015_10) 

Elder Toxicology: Characterizing Unintentional Pharmaceutical Exposures in the Aged Population Using the ToxIC Registry. (P.I. Boroughf, Project #2015_10)

Electrocardiographic QRS Widening Following Quetiapine Exposure (P.I. Oost, Project #2013_04_C)

Endotracheal Intubation for Toxicologic Exposures: a Retrospective Review of Toxicology Investigators Consortium (ToxIC) Cases. (P.I. Hatten, Project #2014_25) 

Extracorporeal Membrane Oxygenation for Severe Toxicologic Exposures (P.I. Wang, Project #2014_03)


Improving Sentinel Reporting in a Medical Toxicology Surveillance System by Strengthening Data Entry Requirements. (P.I. Campleman, Project #2015_09) 

In3 Early Warning System Network for Emerging Drugs of Abuse (P.I. Boyer, Project #2014_17_C)

Initial Glimpses from Medical Toxicology Consultation Services in Russia, Thailand, and Mexico. (International Sub Registry - Suspended)


Medical Consequences of Naloxone Administration (P.I. Yanta, Project #2016_01)

Medical Toxicology Consult: Synthetic Cannabinoids (P.I. Monte, Project #2015_09)

Medications Associated with Serotonin Toxicity (Hendrickson, Project #2012_03_C)

Metal-on-Metal Hip Joint Prostheses: a Retrospective Case Series Investigating Association of Systemic Toxicity with Serum Cobalt and Chromium concentrations (P.I. Brent, Project #2014_05_S)

Metformin Intentional Overdose and its Association with Metabolic Acidosis and Elevated Lactate—As Reported by Medical Toxicologists (P.I. Fernandez, Project #2015_11)


Naltrexone Use and Opioid Withdrawal (P.I. Repplinger, Project #2015_14)


Pesticide Poisonings reported to the Toxicology Investigators Consortium Registry (P.I. Vohra, Project #2012_04)


Quetiapine and QRS Study (P.I. Oost, Project #2013_04_C)


Referral Pattern and Outcomes of Outpatient Medical Toxicology Patient Encounters in the ToxIC Registry (P.I. Nikolaides, Project #2015_13) 

Respiratory Depression and Ventilatory Support in Synthetic Cannabinoid Exposures: Report from the ToxIC Registry (P.I. Callelo, Project #2014_09)


Serotonin toxicity: Case characteristics and associated medications/drugs (P.I. Hendrickson, Project #2012_03_C)

Single Drug Ingestions Associated with Rhabdomyolysis (P.I. Stephani, Project #2014_16)

Snakebite Neurotoxicity: a Retrospective Review of Patients Reported to the ToxIC North American Snakebite Registry (see Sub Registry Projects: NASBR)

Suicidal Adolescents: Examining Self-poisonings within the Pediatric Population (P.I Farrugia, Project #2014_23)

Synthetic THC Study (P.I. Froberg, 2012_05_C)


Toxic Exposures in Young Children Resulting in Tracheal Intubation. (P.I. Hatten, Project #2014_25)

The Current Status of the Practice of Inpatient Medical Toxicology at the Bedside in the US. 

The Practice of Medical Toxicology in the US.

Themes and Trends in Serious Intentional Self-Poisoning. 

ToxIC Cool: Therapeutic Hypothermia After Toxin-Induced Cardiac Arrest (P.I. Modisett, Project #2013_05_S)


Unintentional Pediatric Opioid Exposures Reported to the ToxIC Case Registry.