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Prescription Opioids Misuse Subregistry

Background

Prescription opioid misuse and dependence have become an epidemic in the United States. Although these are commonly encountered exposures, little is known about the demographic characteristics of patients presenting for emergency care for misuse use of prescription opioids that prompts medical toxicology consultation. In addition, less is known about the source of these medications. Medical toxicologists enjoy the unique opportunity to interact with these patients during vulnerable moments and are able to obtain valuable information to help understand the misuse epidemic.

Current definitions of prescription drug abuse are inadequate to describe the ongoing epidemic. Abuse, misuse, and nonmedical use are all terms applied to the problem. Much of what is known about opioid misuse use derives from patient treatment programs for drug addiction and rehabilitation or from national surveys of high school and college students. The prospective collection of data relating to these problems by expert consulting medical toxicologists may lead to important information that may mitigate the current epidemic.

The purpose of ACMT’s ToxIC Registry for Prescription Opioid Misuse is to gather de-identified, detailed prospective information regarding the misuse use of these analgesics. It is designed to help answer questions about the demographics of users and how they obtained the prescription opioids they used. It also is intended to evaluate the frequency of accessing and the utility of the state Prescription Drug Monitoring Program databases. The ultimate goal is to use the information gathered in the Registry to decrease morbidity and mortality resulting from the misuse of prescription opioids.

The primary objective of the Prescription Opioid Misuse Registry is to describe the demographic characteristics of patients presenting for emergency care after prescription opioid misuse resulting in medical toxicology consultation and to identify the source of these medications. The secondary objective is to assess the utility and frequency with which the initial emergency provider and/or the consulting medical toxicologist access the Prescription Drug Monitoring Program while evaluating patients presenting for emergency care after prescription opioid misuse resulting in medical toxicology consultation.

Authorship Guidelines for the Prescription Opioids Misuse Registry

All medical toxicologists who contribute cases to the registry may be listed as members of the ToxIC Registry for the Misuse of Prescription Opioids Group, which will be credited in all publications stemming from the registry to the degree permitted by the editorial policies of any journal to which submissions are made. Individuals with significant administrative involvement in the development and maintenance of the registry will also be considered part of the group and are eligible for individual authorship.

Individually listed authors will include 1-2 investigators from the site contributing the most cases to the registry, as well as a single investigator from the next two sites with the highest case contribution.

The lead author for any sub-study will be a site investigator who has contributed at least ten cases to the registry and who has submitted and received approval for a research proposal to the ACMT Research Committee.

All authors must meet the following requirements: 1) substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; 2) drafting the article or revising it critically for important intellectual content; and 3) final approval of the version to be published.

Principal Investigators Contact Information

Colleen M. Rivers, MD and Shawn M. Varney, MD COL USAF (US).

Email: colleenmarierivers@gmail.com, smvarney@gmail.com.

Download the form for Opioids Misuse Registry